"Our condition? It is a byproduct of the curse given Caine by God. Caine grew lonely in his eternal exile and sought to create eternal companions and loved ones with whom to spend the rest of his unendable existence with. Those friends and lovers grew lonely in turn and created their own children from those they loved and cherished and respected the most as mortals. Those children fought amongst each other and grew hungry for power, and they created their own brood in turn and slew their fathers and mothers with the help of those children. Our father, Lasombra, was among them, though I was not alive when he did his wicked deed - for our father never made a single childe who he deemed worth keeping until Montano, and thereafter myself and Gratiano, and some few others. Caine was furious at the death of his children, and he smote each of his traitorous grandchilder with a terrible curse that can be felt through the blood to this day.
You wish to know what I think about our curse, Anton? It isn't God who cursed us. God cursed Caine. Then Caine cursed his lover, and his friend, to heal his heart. Then they cursed our founders, to heal their hearts. Then those founders cursed me, to further their ambitions. I cursed my children out of respect, and a desire to see them not die. My children embraced for a variety of reasons. Basilio embraced you out of pragmatism, and came to find love. That is what the curse is, not some directive of the Lord, but a product of our weakness. Something that was given to you by your sire and your sire alone, for selfish reasons - yes, even the curse I passed on myself. That same power, to curse someone to your own fate - it lies in your hands as well.
But you should know that, shouldn't you? You embraced Joseph for the most selfish reason of all, the same reason Caine first passed on his curse."
A pause then, "Forgive me, I shouldn't have intruded. Your guilt lies close to the surface of your mind."